Department of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan; Department of Neurology, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan. Electronic address: miyaue@m.ehime-u.ac.jp. Department of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan. Department of Neurology, Saiseikai Matsuyama Hospital, Matsuyama, Ehime, Japan.